Glycosaminoglycans in Scleroderma and Scleredema
Copyright policy )Glycosaminoglycans in Scleroderma and Scleredema
Skin from 6 patients with scleroderma, 3 with scleredema and 5 normal controls were subjected to qualitative and quantitative analysis of glycosaminoglycans. Glycosaminoglycans were identified by cetylpyridinium chloride-salt fractionation and by cellulose acetate electrophoresis. Our data suggest that in scleredema there may be an increase in hyaluronic acid while the concentration of dermatan sulfate is normal. All scleroderma specimens revealed a marked increase in dermatan sulfate.
- Drexel University United States
Adult, Electrophoresis, Male, Scleroderma, Systemic, Scleredema Adultorum, Biopsy, Cell Biology, Dermatology, Middle Aged, Sulfuric Acids, Biochemistry, Scleroderma, Localized, Humans, Female, Hyaluronic Acid, Molecular Biology, Chondroitin, Glycosaminoglycans, Skin
Adult, Electrophoresis, Male, Scleroderma, Systemic, Scleredema Adultorum, Biopsy, Cell Biology, Dermatology, Middle Aged, Sulfuric Acids, Biochemistry, Scleroderma, Localized, Humans, Female, Hyaluronic Acid, Molecular Biology, Chondroitin, Glycosaminoglycans, Skin
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