Business process (BP) literature promotes the value of business processes as essential gearwheels that help organizations to reach their goals. Similarly, many process design approaches claim that information technology (IT) is a major enabler of business process, a view also shared by the information systems (IS) community. Despite this, BP and IS approaches do not provide clear guidance on how to assess the benefits that a given IS design may bring to the BP prior the IS implementation. Nor is clear indication of which modeling techniques could be used to assess such relationship. We use the insights gained during a UK funded research project, namely ASSESS-IT, that aimed to depict the dynamic relationships between BP and IT to propose an alternative framework to develop BP simulation models that depict the dynamic behavior of the relationships between BP and IS.