In mobile communications networks, system capacity is often limited by cochannel interference. Therefore, receiver algorithms for cancellation of cochannel interference have recently attracted much interest. At the mobile terminal, algorithms can usually rely only on one received signal delivered by a single receive antenna. In this letter, a low-complexity single antenna interference cancellation (SAIC) algorithm for real-valued modulation formats referred to as mono interference cancellation (MIC) is introduced which is well suited for practical applications. Field trials in commercial GSM networks using prototype terminals with the proposed MIC algorithm have demonstrated that the novel concept may yield capacity improvements of up to 80%. The underlying principle is also beneficial for adjacent channel interference and receivers with multiple antennas. Furthermore, in coverage-limited scenarios, there is no performance degradation compared with conventional receivers