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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE Transactions on...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
IEEE Transactions on Systems Man and Cybernetics Part C (Applications and Reviews)
Article . 2012 . Peer-reviewed
License: IEEE Copyright
Data sources: Crossref
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Using Multidimensional Bayesian Network Classifiers to Assist the Treatment of Multiple Sclerosis

Authors: Juan Diego Rodríguez; Aritz Pérez Martínez; David Arteta; Diego Tejedor; José Antonio Lozano 0001;

Using Multidimensional Bayesian Network Classifiers to Assist the Treatment of Multiple Sclerosis

Abstract

Multiple sclerosis is an autoimmune disorder of the central nervous system and potentially the most common cause of neurological disability in young adults. The clinical disease course is highly variable and different multiple sclerosis subtypes can be defined depending on the progression of the severity of the disease. In the early stages, the disease subtype is unknown, and there is no information about how the severity is going to evolve. As there are different treatment options available depending on the progression of the disease, early identification has become highly relevant. Thus, given a new patient, it is important to diagnose the disease subtype. Another relevant information to predict is the expected time to reach a severity level indicating that assistance for walking is required. Given that we have to predict two correlated class variables: disease subtype and time to reach certain severity level, we use multidimensional Bayesian network classifiers because they can model and exploit the relations among both variables. Besides, the obtained models can be validated by the physicians using their expert knowledge due to the interpretability of Bayesian networks. The learning of the classifiers is made by means of a novel multiobjective approach which tries to maximize the accuracy of both class variables simultaneously. The application of the methodology proposed in this paper can help a physician to identify the expected progression of the disease and to plan the most suitable treatment.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
29
Top 10%
Top 10%
Top 10%
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