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IEEE Transactions on Neural Systems and Rehabilitation Engineering
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Optimizing Neural Recording Front-Ends Toward Enhanced Spike Sorting Accuracy in High-Channel-Count Systems

Authors: Yunzhu Chen; Xiaolin Yang; Georges Gielen; Carolina Mora Lopez;

Optimizing Neural Recording Front-Ends Toward Enhanced Spike Sorting Accuracy in High-Channel-Count Systems

Abstract

Spike sorting is a pivotal signal-processing technique used to extract information from raw extracellular recordings. Its performance is influenced by the characteristics of the neural recording front-end. This study explores how design choices in amplifiers, filters, and analog-to-digital converters (ADCs) affect the accuracy of well-established spike sorting algorithms. Our primary objective is to identify the minimal requirements that ensure high sorting accuracy while facilitating power- and area-efficient analog front-ends, which is especially needed for multi-channel recording-only applications. To achieve this, we use both synthetic and real datasets, serving as ground truth, processed through a generic MATLAB model of a neural recording front-end that simulates key electrical parameters impacting the signal integrity. These include the filter order and cutoff frequency, ADC resolution, ADC sampling frequency, and nonlinearity. Our findings indicate that optimal spike-sorting results are obtained with a 1st-order bandpass Butterworth filter ranging from 700 Hz to 7.5 kHz, coupled with an ADC that offers a 15-kHz sampling frequency at 8-bit resolution and no missing codes. These insights are crucial for designing high-channel-count neural interfaces where CMOS circuits must efficiently be optimized.

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Keywords

Technology, Extracellular, Biomedical Engineering, Action Potentials, RM1-950, Spike sorting, Harmonic distortion, Sensitivity and Specificity, Engineering, 0903 Biomedical Engineering, Medical technology, Animals, Humans, Computer Simulation, high channel count, R855-855.5, PROBE, Engineering, Biomedical, Accuracy, 4003 Biomedical engineering, Neurons, Mathematical models, Science & Technology, Signal to noise ratio, Amplifiers, Electronic, 4007 Control engineering, mechatronics and robotics, Sorting, LARGE-SCALE, Rehabilitation, Reproducibility of Results, neural-recording front-end, Filters, Signal Processing, Computer-Assisted, Equipment Design, 0906 Electrical and Electronic Engineering, extracellular recording, Recording, Therapeutics. Pharmacology, Noise, Life Sciences & Biomedicine, Algorithms, Analog-Digital Conversion

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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