Magnetic flux leakage (MFL) response predicting is important for defect estimation. This paper first proposes a concept of basic signal by discovering the combination property of the MFL response. The basic signal can be used to predict the MFL response conveniently by a basic signal combination method (BSCM), which is also innovatively put forward in this paper. In this method, the basic signal is calculated in advance, and the MFL response can be calculated by several transformation and combination operations. Both the simulation and experimental results demonstrate the feasibility of BSCM. Compared with other traditional methods (magnetic dipole method and finite-element method), BSCM shows a good performance on both the computational speed and accuracy.