Keyframe selection has been crucial for effective and efficient video content analysis. While most of the existing approaches represent individual frames with global features, we, for the first time, propose a keypoint-based framework to address the keyframe selection problem so that local features can be employed in selecting keyframes. In general, the selected keyframes should both be representative of video content and containing minimum redundancy. Therefore, we introduce two criteria, coverage and redundancy, based on keypoint matching in the selection process. Comprehensive experiments demonstrate that our approach outperforms the state of the art.