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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE/ACM Transaction...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Article . 2010 . Peer-reviewed
License: IEEE Copyright
Data sources: Crossref
DBLP
Article . 2010
Data sources: DBLP
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Reassortment Networks for Investigating the Evolution of Segmented Viruses

Authors: Shahid H. Bokhari; Daniel Janies;

Reassortment Networks for Investigating the Evolution of Segmented Viruses

Abstract

Many viruses of interest, such as influenza A, have distinct segments in their genome. The evolution of these viruses involves mutation and reassortment, where segments are interchanged between viruses that coinfect a host. Phylogenetic trees can be constructed to investigate the mutation-driven evolution of individual viral segments. However, reassortment events among viral genomes are not well depicted in such bifurcating trees. We propose the concept of reassortment networks to analyze the evolution of segmented viruses. These are layered graphs in which the layers represent evolutionary stages such as a temporal series of seasons in which influenza viruses are isolated. Nodes represent viral isolates and reassortment events between pairs of isolates. Edges represent evolutionary steps, while weights on edges represent edit costs of reassortment and mutation events. Paths represent possible transformation series among viruses. The length of each path is the sum edit cost of the events required to transform one virus into another. In order to analyze tau stages of evolution of n viruses with segments of maximum length m, we first compute the pairwise distances between all corresponding segments of all viruses in O(m2n2) time using dynamic programming. The reassortment network, with O(taun2) nodes, is then constructed using these distances. The ancestors and descendents of a specific virus can be traced via shortest paths in this network, which can be found in O(taun3) time.

Related Organizations
Keywords

Gene Rearrangement, Models, Genetic, Birds, Evolution, Molecular, Influenza A virus, Animals, Humans, Algorithms, Phylogeny, Reassortant Viruses

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Average
Top 10%
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