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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao IEEE Transactions on...arrow_drop_down
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IEEE Transactions on Biomedical Engineering
Article . 2025 . Peer-reviewed
License: IEEE Copyright
Data sources: Crossref
DBLP
Article . 2025
Data sources: DBLP
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Deep Network Regularization for Phase-Based Magnetic Resonance Electrical Properties Tomography With Stein's Unbiased Risk Estimator

Authors: Chuanjiang Cui; Kyu-Jin Jung; Mohammed A. Al-Masni; Jun-Hyeong Kim; Soo-Yeon Kim; Mina Park; Shao Ying Huang; +2 Authors

Deep Network Regularization for Phase-Based Magnetic Resonance Electrical Properties Tomography With Stein's Unbiased Risk Estimator

Abstract

Magnetic resonance imaging (MRI) can estimate tissue conductivity values using phase-based magnetic resonance electrical properties tomography (MR-EPT). However, this method is prone to noise amplification due to the Laplacian operator's sensitivity. To address this issue, we propose a novel unsupervised preprocessing denoiser for MRI transceive phase images. Our approach draws inspiration from the deep image prior (DIP) technique, utilizing the random initialization of a convolutional neural network (CNN) to enforce implicit regularization. Additionally, we incorporate Stein.s unbiased risk estimator (SURE) to optimize the network, which serves as an unbiased estimator of mean square error, thereby eliminating the need for labeled data. This modification mitigates the overfitting commonly associated with the DIP approach, enabling a fully unsupervised framework. Furthermore, we process real and imaginary images instead of phase images, aligning more closely with the theoretical basis of the risk estimator. Our generative model does not require pre-training or extensive training datasets, maintaining adaptability across different resolutions and signal-to-noise ratio levels. In our evaluations, the proposed method significantly reduced residual noise in phase maps, improving both quantitative and qualitative outcomes in phantom and simulated brain data. It also outperformed existing denoising techniques by reducing noise amplification and boundary errors. Applied to data from healthy volunteers and patients, our method yielded conductivity maps with reduced errors and values consistent with established literature. To our knowledge, this is the first blind, fully unsupervised approach capable of implementing a 2D phase-based MR-EPT reconstruction algorithm.

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Keywords

Deep Learning, Phantoms, Imaging, Image Processing, Computer-Assisted, Humans, Brain, Neural Networks, Computer, Signal-To-Noise Ratio, Magnetic Resonance Imaging, Tomography, Algorithms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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