An instrumentation scheme for performing computerized heart catheterization has been developed. Objectives in the development were 1) low cost, 2) stability, 3) reliability, and 4) simplicity of operation. These objectives were achieved by using integrated-circuit operational-amplifier techniques coupled with simplified noninteractive controls. Use of the equipment in four hospitals over the past four years on over 1500 catheterizations has shown it to be ideal for heart catheterizations and other clinical and experimental settings where cardiovascular measurements are made.