As more defense systems are dependent on software, there has been increased interest in applying agile software development and delivery in Department of Defense (DoD) programs which are managed under DoD acquisition policy and guidance. Systems engineering guidance in the “Defense Acquisition Guidebook” [1] defines 16 systems engineering technical and technical management processes, which align to the systems engineering processes in ISO 15288 [2]. These processes are applied across DoD acquisition programs. This paper discusses how programs using an agile software development approach can tailor these processes to provide discipline and rigor to their acquisition program.