In this paper, a new meta-heuristic optimization algorithm called Grey Wolf Optimizer (GWO) is applied to offshore crane design. An offshore crane is a pedestal-mounted elevating and rotating lifting device used to transfer materials or personnel to or from marine vessels, barges and structures whereby the load can be moved horizontally in one or more directions and vertically. Designing and building offshore cranes is a very complex process. It depends on the configuration of a large set of design parameters and is characterized by increased workability and functionality for the owner and cost effectiveness in the total cost of ownership. In an attempt to reduce time and cost involved in the design process, this paper defines a best set of design parameters and uses GWO for the automatic configuration of this set of parameters in a manner that increases the maximum safe working load of the crane and reduces its total weight. Results are verified by a comparative study with other Evolutionary Algorithms (EAs). Results show that the GWO algorithm is able to provide very competitive results compared to these well-known meta-heuristics.