In this paper, we present "Smartweed", a Locationbased application developed within DATABENC, a high technology district for Cultural Heritage management. In particular, the project aims at exploiting several location-based services and technologies to realize a smart multimedia guide system able to detect the closest artworks to an user, make them able to "tweet" and "talk" during tourists' visit and capable of automatically telling their stories using multimedia facilities. Moreover, we have deployed and tested the installation of some sensors that, using Wi-Fi technology, allow to the users' mobile devices to detect the closest artwork in a museum environment. Once an artwork has been detected, the related identifier is retrieved and a multimedia story is delivered to user by means of proper multimedia delivery and user-profiling techniques, in order to facilitate and make more stimulating the visit. The artworks detection was performed by a localization algorithm that we designed and tested in our laboratory rooms. As case of study, we show an example of "tweeting and talking artworks" as a location-based application of a sculptures' art exhibition within the Maschio Angioino castle, in Naples - Italy.