Here, we firstly report the detection of phospholiposomes by the highly sensitive microfabricated piezoresistive cantilever sensor chip and the phosphatidylserine (PS) recognition protein C2A which is chemically immobilized on the sensor surface. The signal created from the bending motion of the piezoresistive cantilever after the phospholiposome attachment has been monitored in real time. And the sensitivity of the sensor was determined judging from the co-relationship between electrical signal and the number of liposome particles.