Medication adherence is one of the most complex and persistent challenges in healthcare. Solutions have been designed with varying degrees of success. Here, the authors present a roadmap that shows how emerging IT can play a major role in improving medication adherence. Specifically, they discuss five major technologies for medication adherence: smartphone apps, smart medication boxes, smart pills, sensors, and implantable devices. They show how these technologies support and integrate into a roadmap for higher medication adherence. The hope is that IT professionals will address many of the challenges and opportunities identified in the article.