A transformation is underway regarding how we deal with our health, not only because mobile Internet technology has made it possible to have continuous access to personal health information, but also because breaking the trend of ever-growing healthcare costs is increasingly necessary. Connectivity, interoperability, sensing, and instant feedback through smartphones all provide new opportunities for gaining insights into our health behavior. Such insights improve our understanding of what motivates people to make healthier changes throughout their lifetimes. Thus, this special issue reviews and shares advances in wireless, connected, and mobile health research that expand the possibilities.