This issue of the Series presents two articles in the area of cloud and edge computing. The first article is an exemplary of the IoT ecosystem that receives momentum for use in smart cities, public safety, and e-health. Fabio Giust et al. present a multi-access edge computing (MEC) architectural solution that allows for seamlessly integrating existing and future IoT platforms. The authors additionally present an IoT gateway middleware that enables running low-latency and/ or computationally intensive applications on generalized MEC-based systems.