Wireless capsule endoscopy (WCE) has conquered some limitations of traditional diagnosing tools, such as the comfortlessness of the cables and the inability of examining small intestine section. However, this technique is still far from satisfactory and requires some feasible improvements. Antenna plays an important role for transmitting and receiving signals. Therefore, the design of a WCE transmitter antenna has been investigated in this paper. Two proposed patch antennas are designed and optimized in this paper. These proposed designs are meeting the requirements for WCE system which includes operating frequency, bandwidth, return loss, and small in size.