
pmid: 19163206
An action potential is generated when the membrane potential of a spiking neuron reaches a certain threshold. Although it is well-known that the threshold level of a neuron is not a fixed value and changes with time and neuronal parameters, its variation is often ignored in neuronal modeling due to the complexity of the analysis. Assuming a fixed threshold level, however, may produce non-realistic results. If we find a model to incorporate the impact of the variation of the threshold in a fixed threshold model we can benefit from the simplicity of the existing fixed-threshold models yet obtain more realistic results. It is shown here that, with some approximations, we can create a fixed threshold model for an integrate-and-fire neuronal model from an adjustable threshold model by some simple operations. Both models generate the same spike (action potential) pattern.
Neurons, Models, Statistical, Time Factors, Models, Neurological, Electric Conductivity, Presynaptic Terminals, Action Potentials, Differential Threshold, Reproducibility of Results, Models, Biological, Synaptic Transmission, Electric Stimulation, Membrane Potentials, Humans
Neurons, Models, Statistical, Time Factors, Models, Neurological, Electric Conductivity, Presynaptic Terminals, Action Potentials, Differential Threshold, Reproducibility of Results, Models, Biological, Synaptic Transmission, Electric Stimulation, Membrane Potentials, Humans
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