
pmid: 18002941
Central (large airway) and peripheral (small airway) dysfunction frequently occur in patients with asthma and chronic obstructive lung disease. Measurement of the respiratory impedance can assist with diagnosis of pathological conditions. The forced Oscillation technique (FOT) superimposes small pressure perturbations at the mouth during tidal breathing of a subject to measure lung mechanical parameters. The Impulse Oscillometry System (IOS) is a commercial instrument that measures forced oscillatory impedance. IOS can be conveniently used in children as it only requires their passive cooperation during pulmonary function testing. Forced oscillatory impedance can be analyzed with respiratory system equivalent electrical circuit models. Models of varying complexity and fidelity have been developed to provide better understanding of respiratory mechanics and enable greater specificity of the diagnosis. Parameter estimates for these models can be used as reference values for detection and diagnosis of different respiratory pathologies. Previous work by our group has evaluated several known respiratory models and a new RIC model (augmented RIC) has emerged which offers advantages over earlier models. It has been shown that one parameter of this new model (representing peripheral airway compliance) is capable of discriminating between normal and asthmatic children. In this paper, we analyzed IOS data from 40 Hispanic asthmatic children and obtained sensitive impulse oscillometric parameters of lung function as well as parameter estimates for the augmented RIC (aRIC) model to distinguish between constricted (asthmatic condition) and non-constricted (non-asthmatic condition) airways with very promising results.
Male, Forced Expiratory Flow Rates, Hispanic or Latino, Models, Biological, Asthma, Pulmonary Disease, Chronic Obstructive, Child, Preschool, Electric Impedance, Respiratory Mechanics, Tidal Volume, Humans, Female
Male, Forced Expiratory Flow Rates, Hispanic or Latino, Models, Biological, Asthma, Pulmonary Disease, Chronic Obstructive, Child, Preschool, Electric Impedance, Respiratory Mechanics, Tidal Volume, Humans, Female
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 1 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
