
pmid: 17947070
We propose hybrid automata (HA) as a unifying framework for computational models of excitable cells. HA, which combine discrete transition graphs with continuous dynamics, can be naturally used to obtain a piecewise, possibly linear, approximation of a nonlinear excitable-cell model. We first show how HA can be used to efficiently capture the action-potential morphology--as well as reproduce typical excitable-cell characteristics such as refractoriness and restitution--of the dynamic Luo-Rudy model of a guinea-pig ventricular myocyte. We then recast two well-known computational models, Biktashev's and Fenton-Karma, as HA without any loss of expressiveness. Given that HA possess an intuitive graphical representation and are supported by a rich mathematical theory and numerous analysis tools, we argue that they are well positioned as a computational model for biological processes.
Heart Ventricles, Guinea Pigs, Models, Cardiovascular, Models, Biological, Automation, Nonlinear Dynamics, Artificial Intelligence, Oscillometry, Animals, Myocytes, Cardiac, Algorithms
Heart Ventricles, Guinea Pigs, Models, Cardiovascular, Models, Biological, Automation, Nonlinear Dynamics, Artificial Intelligence, Oscillometry, Animals, Myocytes, Cardiac, Algorithms
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