Non-viral Charge Reversal Vectors for pDNA Delivery

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 01 Aug 2006Publisher:IEEEJournal:2006 International Conference of the IEEE Engineering in Medicine and Biology Society

Authors: Carla A. H. Prata; Yougen Li; Dan Luo; Thomas J. McIntosh; Mark W. Grinstaff;

doi: 10.1109/iembs.2006.260181 , 10.1109/iembs.2006.4398414

pmid: 17946624

Non-viral Charge Reversal Vectors for pDNA Delivery

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Abstract

A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids.

Related Organizations

Boston University
United States
Cornell University
United States
Duke Medical Center
United States

Keywords

Anions, Light, Genetic Vectors, Gene Transfer Techniques, CHO Cells, DNA, Lipids, Cricetulus, Microscopy, Electron, Transmission, X-Ray Diffraction, Cricetinae, Animals, Humans, Scattering, Radiation, K562 Cells

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