The problem of interfacing microsystems to neurons or brain has led to exciting developments in the fields of micro/nanotechnologies and integrated circuitry and systems. Neurons have been patterned using micro/nanotechnologies to form structural and functional networks. Micro-electrodes and integrated circuitry have been developed for large scale, multichannel measurements from brain tissue. Driving force for this technology comes from research and clinical interest in the emerging fields of neural prosthesis, deep brain stimulations and brain-machine interface. This review presents some examples of the work done in the field of neural patterning, tissue interfacing, electrodes, recording and system integration.