Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins

B. Grzybowski; S. Tong; R.W. Compans; J.M. Le Doux

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https://doi.org/10.1109/iembs....

Article . 2003 . Peer-reviewed

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https://dx.doi.org/10.1109/iem...

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Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins

descriptionPublicationkeyboard_double_arrow_right Article 26 Jun 2003Publisher:IEEEJournal:Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, volume 1, pages 539-540

Authors: B. Grzybowski; S. Tong; R.W. Compans; J.M. Le Doux;

doi: 10.1109/iembs.2002.1136939

Lentivirus vector pseudotyped with human parainfluenza virus type 3 glycoproteins

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Abstract

Lentiviral vectors pseudotyped with the envelope glycoproteins of amphotropic murine leukemia virus and the G protein of vesicular stomatitis virus have been previously developed for use in human gene therapy trials. We report here the generation of infectious replication-defective HIV-1 particles pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins derived from human parainfluenza virus type 3 (HPIV3). The HIV-1(HPIV3) pseudotype vectors may have unique properties that will make them useful for efficient gene transfer into a variety of human tissues for the purposes of human gene therapy.

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