
A method for fabricating high-density oligonucleotide arrays directed by a set of molecular stamps is reported in this paper. In this method, based on the standard phosphoramidites chemistry protocol, the coupling was conducted under soft lithography. A 20-mer DNA microarray with 10,000 probes has been successfully fabricated, which shows the advantages of accurate, reliable operation and low-cost production of high-density DNA chips.
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