This paper describes a new technique to simulate MATLAB system models in PSpice environment. The algorithmic component of the design is developed using MATLAB, and then exported to a C-model which can be read and simulated by PSpice using its newly developed PSpice Device Modeling Interface (DMI). The paper describes in detail the changes required to make the MATLAB C-Model compatible with PSpice device modeling requirements. Once circuit simulations using PSpice are signed-off, the algorithmic module can be targeted to FPGA, SOC or PCB for implementation.