We have been developing a lot of medical image applications in collaboration with medical researchers during the COE program period. In this article, we will introduce three of our applications briefly. Title of each topics are, "Image based retrospective cardiac gating and spatio temporal image mosaicing of CAG", "Myocardialperfusion measurements from CAG", and "Registration of preoperative 3-D CT with intraoperative fluoroscopic 2-D image sequnce". All these topics are related to dynamic image processing of cardiovascular disease images