spread spectrum is a technique that the transmitted signal is spreaded over a broader portion of the radio frequency band, by means of a code independent of the data. This technique will however allow a better performance over a fading channel, inherent privacy, and immunity to narrowband interference. FCC has restricted the commercial use of the technology due to the increased frequency space it occupies. Therefore, step has to be taken to overcome the co-existence of wireless devices over this radio band. In this paper, we propose to adopt blind source separation techniques for interference mitigation in ISM band. These techniques strive to separate a mixture of N independent non-Gaussian signals received on an array of sensors and as such produce a signal with reduced jammer contamination. With the jammer mostly mitigated through the separation process, the SS system required smaller spreading gain and transmission bandwidth than the case if no separation is performed. Simulation results including other algorithms are provided to illustrate the effectiveness of the proposed approach.