Ising machines have attracted attention as they are expected to solve combinatorial optimization problems at high speed with Ising models corresponding to those problems. An induced subgraph isomorphism problem is one of the decision problems, which determines whether a specific graph structure is included in a whole graph or not. The problem can be represented by equality constraints. By using the penalty functions correspond to the equality constraints, we can utilize an Ising machine to the induced subgraph isomorphism problem. The induced subgraph isomorphism problem can be seen in many practical problems, for example, finding out a particular malicious circuit in a device or particular network structure of chemical bonds in a compound. However, due to the limitation of the number of spin variables in the current Ising machines, reducing the number of spin variables is a major concern. Here, we propose an efficient Ising model mapping method to solve the induced subgraph isomorphism problem by Ising machines. Our proposed method theoretically solves the induced subgraph isomorphism problem. Furthermore, the number of spin variables in the Ising model generated by our proposed method is theoretically smaller than that of the conventional method. Experimental results demonstrate that our proposed method can successfully solve the induced subgraph isomorphism problem using the Isingmodel based simulated annealing.