Hydrogels based on natural polysaccharides are found to be so appealing for wound healing applications. The present study deals with the synthesis and characterization of PVA/acacia gum hybrid hydrogels where Arabic gum was evaluated as network properties improvement factor in hybrid hydrogel with the capability of antimicrobial agent (erythromycin) delivery in wound site. The comparison of drug release from mentioned hydrogel wound dressing with pure PVA hydrogel in stimulated wound fluid, swelling studies as a function of additive type, pH and temperature has been discussed. Eventually, the hybrid film was characterized by SEM. All of the observed results indicate that the hybrid hydrogel could easily be used as functional wound dressing to control the rate of antibiotic drug release to the wound site.