Electro spun nanofibres have become an exciting area in biomaterial development, due to their high surface area and porosity. Indeed, many studies on nanofibres have demonstrated their feasibility in various applications, such as promoters for tissue cell adhesion and encapsulations for drugs. However, many challenges faced today are complicated in nature and require a multidimensional approach to solve, necessitating multifunctional products. This work explored recent efforts in developing a new class of active nanofibers for wound care. Ensuring satisfactory wound healing is often difficult due to the dynamic nature of the skin, requiring fulfilment of multiple objectives at different stages of the healing process. We demonstrated that by controlling therapeutic agents release from wound dressing, its mechanical responses to the wound and in aqueous environment, a wound dressing capable of interacting with different wounds can be developed.