AbstractIncreasingly, complex scientific applications are structured in terms of workflows. These applications are usually computationally and/or data intensive and thus are well suited for execution in grid environments. Distributed, geographically spread computing and storage resources are made available to scientists belonging to virtual organizations sharing resources across multiple administrative domains through established service‐level agreements. Grids provide an unprecedented opportunity for distributed workflow execution; indeed, many applications are well beyond the capabilities of a single computer, and partitioning the overall computation on different components whose execution may benefit from runs on different architectures could provide better performances. In this paper we describe the design and implementation of the Grid Resource Broker (GRB) workflow engine. Copyright © 2008 John Wiley & Sons, Ltd.