The quality of mobile communications have been severely affected by interference among users in TD-SCDMA, in allusion to this problem, the smart antenna adaptive beam-forming algorithm are researched deeply in the thesis. According to the technical features that smart antenna can adaptive track the user signals realize the design and simulation of smart antenna in interference suppression, and compare and analyze the result then prove the advantage and disadvantage of two algorithms. We simulates the adaptive filter with MATLAB, the results prove that it can suppression interference in TD-SCDMA system with the effectiveness.