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Discontinuous Galerkin Model of Cellular Electroporation

Authors: Daniel C. Sweeney; Rafael V. Davalos;

Discontinuous Galerkin Model of Cellular Electroporation

Abstract

Electroporation (EP) is a phenomenon involving both nonlinear biophysical processes and complex geometries. When exposed to strong electric fields, the formation of pores within a cell membrane increases the membrane permeability. Discontinuous Galerkin (DG) finite element methods can directly enforce these flux jumps across the thin cell membrane interface. We implement a DG finite element method to model the electric field, pore formation, and transmembrane flux of charged solutes during EP. Our model is readily extensible for parallel computation on high performance clusters and agrees with previous reports.

Related Organizations
Keywords

Cell Membrane Permeability, Electroporation, Cell Membrane, Finite Element Analysis, Models, Biological

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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