Colon cancer is a very spread malady at international level, symptoms occurring due to a number of vary conditions that may be totally ignored in early stages. Moreover, even treated surgical or with chemotherapy, lots of patients occur recurrence at a specific period of time, so more validated findings in the microarray analysis field, should improve treatment phases and prognosis in alterated genes evolution. Our research proposes a robust microarray analysis technique for a better understanding of main gene interactions involved in colon cancer, which hopefully will lead to a disease occurrence and progression model prediction.