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Complementary Contextual Models with FM-Index for DNA Compression

Authors: Wenjing Fan; Wenrui Dai; Yong Li 0033; Hongkai Xiong;

Complementary Contextual Models with FM-Index for DNA Compression

Abstract

Demanding for efficient compression and storage of DNA sequences has been rising with the rapid growth of DNA sequencing technologies. Existing reference-based algorithms map all patterns to regions found in the reference sequence, which lead to redundancy of incomplete similarity. This paper proposes an efficient reference-based method for DNA sequence compression that integrates FM-index and complementary context models to improve compression performance. The proposed method introduces FM-index to represent the full-text matching for exact repeats between the target and reference sequences. For unmatched symbols, complementary context models are leveraged to make weighted estimation conditioned on variable-order contexts. Reversed reference index is used to guarantee the longest match of variable-length substrings. Experimental results show that the proposed method can achieve a 213-fold compression ratio when tested on the first Korean personal genome sequence data set.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
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