With the accelerated global urbanization and life rhythm, an increasing physical and mental stress has been imposed, which led to a variety of problems that could not be ignored. This paper proposes a novel web-based telemedicine system that is focusing on psychotherapy. Considering the requirement of the psychological treatment, the function of system contains high definition video monitoring, two-way voice talkback, physiology parameters monitoring and data management based on database. The solution of the system is presented in the paper, including the hardware and software design. Some key issues in the system, including HD video processing, physiological parameters processing, are also discussed. Finally, the demonstration system and performance evaluation are presented.