This paper focused on the analysis of LTE FDD and TD-LTE combination network's interference. Firstly, deterministic analysis was used to analyze the interference between base stations of LTE FDD and TD-LTE, and the required additional isolation for system's coexistence is calculated. Then with system simulation method, the loss of system throughput caused by the interference of TD-LTE base station uplink and downlink to LTE FDD base station uplink, when shares a common base station, is drew, and the minimum filter standard desired for the normal work of two systems is obtained. On this basis, the paper proposed anti-jamming measures under combination network, which has an important guiding significance for the interference problems in the construction of LTE FDD and TD-LTE combination network.