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MAPK Signaling Pathways and Their Recursive Modularization

Authors: Rajat De; Losiana Nayak;

MAPK Signaling Pathways and Their Recursive Modularization

Abstract

Signal transduction pathways are very complex biochemical networks that include a large number of vital biomolecules and chemical compounds whose activities are dependent on member(s) involved in the network under consideration as well as other networks. Modularized study of such networks will be more appropriate for deciphering the underlying mechanisms that control physiological behavior of cell(s). Here we have proposed an algorithm for modularizing signal transduction network which is applied to MAPK pathway of D. melanogaster and H. sapiens. The idea "a member whose activity is controlled by maximum number of other members in the network under consideration, tends to be the center of a module" is used to divide a network into different modules. These modules are created by taking a certain level of complexity .. into account, i.e., in an expanding module, a member having more than .. relations that lie outside the module, are ignored. Recursive modularization can create modules at different stages of various complexities that finally lead to convergence of the entire network into a single module.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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