
The lymph node structural organization is essential for providing effective immune responses. We present an algorithm to generate 3D voxel-based approximation of the reticular network — the scaffold of T cell zone, consisting of fibroblastic reticular cells enwrapping the conduit system, — from the given conduit system topology graph. The algorithm is based on extended formulation of Cellular Potts Model, in which the intrinsic motility of cells is specified for each voxel according to distributions localized around graph nodes. This approach allows one to maintain the connectivity of network by freezing the cells junctions, to control the target volume fraction of network and the typical sizes of FRC bodies.
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