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Modelling the structural organization of lymph nodes

Authors: Dmitry Grebennikov; Gennady Bocharov;

Modelling the structural organization of lymph nodes

Abstract

The lymph node structural organization is essential for providing effective immune responses. We present an algorithm to generate 3D voxel-based approximation of the reticular network — the scaffold of T cell zone, consisting of fibroblastic reticular cells enwrapping the conduit system, — from the given conduit system topology graph. The algorithm is based on extended formulation of Cellular Potts Model, in which the intrinsic motility of cells is specified for each voxel according to distributions localized around graph nodes. This approach allows one to maintain the connectivity of network by freezing the cells junctions, to control the target volume fraction of network and the typical sizes of FRC bodies.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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