Controlling the ribosomal density profile in mRNA translation

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 01 Dec 2016Publisher:IEEEJournal:2016 IEEE 55th Conference on Decision and Control (CDC)

Authors: Yoram Zarai; Michael Margaliot; Eduardo D. Sontag; Tamir Tuller;

doi: 10.1109/cdc.2016.7798904

Controlling the ribosomal density profile in mRNA translation

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Abstract

During mRNA translation, the ribosomal density profile along the coding region of the mRNA molecule affects various fundamental intracellular phenomena. Thus, steering this profile from a given to a desired density is an important biological problem. This paper studies this problem using a dynamical model for mRNA translation, called the ribosome flow model (RFM), in which one views the transition rates along the mRNA molecule as controls.

Related Organizations

Tel Aviv University
Israel
Rutgers, The State University of New Jersey
United States

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