This paper deals with a decentralized faulttolerant control methodology based on an Active Fault Diagnosis approach. The proposed technique addresses the important problem of monitoring interconnected Large-Scale Systems (LSS). The fault diagnosis approach is made of a passive set-based fault detection method and an active fault isolation technique, able to guarantee isolability subject to local input and state constraints. The proposed scheme can be implemented locally in a decentralized way. A significant feature is the decentralized design constructed on tube-based Model Predictive Control to possibly allow the disconnection of faulty subsystems or the reconfiguration of local controllers. The Active Fault Diagnosis tool is designed to support the decision making process for the control and monitoring of the LSS.