For hybrid closed-loop systems arising from hybrid control of nonlinear systems, we show that the sample-and-hold implementation of the hybrid controller preserves (semiglobally and practically) the stability properties of the closed-loop system. We provide a general model for the hybrid closed-loop system where the hybrid controller is implemented digitally and it is interfaced to the nonlinear system through sample and hold devices. We model the sample device and the digital controller/hold device as single asynchronous hybrid systems with independent timing constants and data. The main result is established by means of a Lyapunov function for the hybrid closed-loop system resulting from the interconnection of its hybrid and nonlinear subsystems.