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Prediction of unstable behavior in enzymatic diffusion-reaction Processes

Authors: Jorge dos Santos; Rogelio Lozano; Alain Friboulet; Sabine Mondié;

Prediction of unstable behavior in enzymatic diffusion-reaction Processes

Abstract

The prediction of the behavior of biological mechanisms represents an important challenge in the comprehension of some disorders in living organisms. In this sense a better understanding of the system behavior is mandatory. In this paper we use mathematical tools and well established concepts of nonlinear dynamics and control for modeling and prediction of the biochemical behavior of an enzyme immobilized into an artificial membrane. The results are helpful to determine the causes of alterations in the enzymatic kinetic properties as well as in the prediction of complex behavior (oscillations) resulting from the catalytic activity. We first study the hydrolysis of Acetilcholine to show that it can be interpreted in terms of a coupling between the enzyme reaction and the diffusion process. The model is then extrapolated to a distributed system in order to analyze its behavior as a function of both time and space.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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