To fulfill the explosive growth of network capacity, fifth generation (5G) standard has captured the attention and imagination of researchers and engineers around the world. In particular, heterogeneous cloud radio access network (H-CRAN), as a promising network paradigm in 5G system, is a hot research topic in recent years. However, the densely deployment of RRHs in H-CRAN leads to downlink/uplink traffic asymmetry and severe inter-cell interference which could seriously impair the network throughput and resource utilization. To simultaneously solve these two problems, we proposed a dynamic resource allocation (DRA) scheme for H-CRAN in TDD mode. Firstly, we design a clustering algorithm to group the RRHs into different sets. Secondly, we adopt coordinated multipoint technology to eliminate the interference in each set. Finally, we formulate the joint frame structure, power and subcarrier selection problem as a mixed strategy non-cooperative game. The simulation results are presented to validate the effectiveness of our proposed algorithm by compared with the existing work.