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Genomic analysis with MapReduce

Authors: Wei-Yi Liu; Hui-I Hsiao; Shih-Yao Dai;

Genomic analysis with MapReduce

Abstract

Genomic analysis [1] usually includes a pipeline of three stages: sequence alignment, data conversion, and advanced analysis. The analysis pipeline needs to handle hundreds of gigabytes of data as well as to run complex analytics algorithms, which traditionally takes long execution time (20+ hours) for a full genomes analysis. Parallelizing the execution of analytics algorithms is one way to speed up the process. Parallelizing genomic analysis is not a simple task, however, as it involves complicated splitting/distribution of data and merging of intermediate results. Our objective is to reduce the genomic analysis time to under an hour. To achieve this, we designed and implemented a distributed analysis pipeline that executes the pipeline in parallel on a Hadoop cluster (physical machines or VM nodes). Since Hadoop already handles work/job dispatching and work balance among distributed worker nodes, we need not handle node failure and load balancing required with a traditional distributed computing approach. Our major challenge is to run the genomic analysis pipeline effectively with Hadoop MapReduce and to ensure the correctness and quality of the analysis results. This paper discusses our work in the design and implementation of a highly parallelized genomic analysis pipeline. Our preliminary experiment results show that our parallelized pipeline using MapReduce improves analysis time by 447% while maintaining the result quality.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
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