Considering the security and efficiency of quantum communication system, one step quantum key distribution protocol based on hyperentangled Bell state is proposed. Every 6 classical bits are divided into a group, which are encoded by single particle and hyperentangled Bell state, the sender Alice sends them to receiver Bob, Bob randomly selects the position of hyperentangled Bell state to measure and detects the existence of eavesdropper Eve by comparing measurement results in his hand and transmitted by Alice. Quantum key distribution protocol based on grouping is proposed to solve the storage problem of quantum information and improve the maneuverability, a security analysis is calculated under the intercept-measure-resend attack which introduce at least an error rate of 46.875%, if Eve wants to get all the information, the probability of detection eavesdropping under the entanglement-measure attack is 93.75%, so it proves that proposed protocol does not need to store the quantum state and asymptotically secure under intercept-measure-resend attack and entanglement-measure attack.