The residual nonuniformity response, ghosting artifacts, and over-smooth effects are the main defects of the existing nonuniformity correction (NUC) methods. In this paper, a spatiotemporal feature-based adaptive NUC algorithm with bilateral total variation (BTV) regularization is presented. The primary contributions of the innovative method are embodied in the following aspects: BTV regularizer is introduced to eliminate the nonuniformity response and suppress the ghosting effects. The spatiotemporal adaptive learning rate is presented to further accelerate convergence, remove ghosting artifacts, and avoid over-smooth. Moreover, the random projection-based bilateral filter is proposed to estimate the desired target image more accurately which yields more details in the actual scene. The experimental results validated that the proposed algorithm achieves outstanding performance upon both simulated data and real-world sequence.