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Buprenorphine

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 03 May 2014Publisher:International Union of Crystallography (IUCr)Journal:Acta Crystallographica Section E Structure Reports Online, volume 70, pages o635-o635 (eissn: 1600-5368,

Authors: Jaroslaw Mazurek; Marcel Hoffmann; Anna Fernandez Casares; Phillip D. Cox; Mathew D. Minardi;

doi: 10.1107/s1600536814009672

pmid: 24940223

pmc: PMC4051008

Buprenorphine

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Abstract

In the crystal structure of a semi-synthetic opioid drug buprenorphine, C29H41NO4{systematic name: (2S)-2-[(5R,6R,7R,14S)-9α-cyclopropylmethyl-3-hydroxy-6-methoxy-4,5-epoxy-6,14-ethanomorphinan-7-yl]-3,3-dimethylbutan-2-ol}, the cyclopropylmethyl group is disordered over two sites with an occupancy factor of 0.611 (3) for the major component. One of the hydroxy groups is involved in intramolecular O—H...O hydrogen bond. The other hydroxy group acts as a proton donor in an intermolecular O—H...O interaction that connects molecules into a zigzag chain along thebaxis.

Keywords

Crystallography, QD901-999, Organic Papers

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