
T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers. We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile. We show that the ensemble-averaged flow profile of a T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed. Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important connection between T1 transitions and mixing in dense systems. Published by the American Physical Society 2024
Physics, QC1-999, FOS: Physical sciences, Quantitative Biology - Tissues and Organs, Condensed Matter - Soft Condensed Matter, Computational Physics (physics.comp-ph), Biological Physics (physics.bio-ph), FOS: Biological sciences, Soft Condensed Matter (cond-mat.soft), Physics - Biological Physics, Tissues and Organs (q-bio.TO), Physics - Computational Physics
Physics, QC1-999, FOS: Physical sciences, Quantitative Biology - Tissues and Organs, Condensed Matter - Soft Condensed Matter, Computational Physics (physics.comp-ph), Biological Physics (physics.bio-ph), FOS: Biological sciences, Soft Condensed Matter (cond-mat.soft), Physics - Biological Physics, Tissues and Organs (q-bio.TO), Physics - Computational Physics
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