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Physical Review Research
Article . 2024 . Peer-reviewed
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Physical Review Research
Article . 2024
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Physical Review Research
Article . 2024 . Peer-reviewed
https://dx.doi.org/10.48550/ar...
Article . 2024
License: CC BY
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From cell intercalation to flow, the importance of T1 transitions

Authors: Harish P. Jain; Axel Voigt; Luiza Angheluta;

From cell intercalation to flow, the importance of T1 transitions

Abstract

T1 transitions, also called cell intercalations, are important sources of fluidization of epithelial cell monolayers. We use a multiphase field model to quantify this tissue fluidization in terms of the relative dispersion of cells and characterize the T1 flow profile. We show that the ensemble-averaged flow profile of a T1 transition has a saddle-point pattern accompanied by a localized burst in cell speed. Although the temporal evolution of the relative dispersion of cells depends on specific model details, the different dispersion curves collapse robustly onto a linear function of the number of T1 transitions, implying an important connection between T1 transitions and mixing in dense systems. Published by the American Physical Society 2024

Keywords

Physics, QC1-999, FOS: Physical sciences, Quantitative Biology - Tissues and Organs, Condensed Matter - Soft Condensed Matter, Computational Physics (physics.comp-ph), Biological Physics (physics.bio-ph), FOS: Biological sciences, Soft Condensed Matter (cond-mat.soft), Physics - Biological Physics, Tissues and Organs (q-bio.TO), Physics - Computational Physics

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    3
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Top 10%
Average
Average
Green
gold